diff --git a/rq/queue.py b/rq/queue.py
index d58c27b..64280de 100644
--- a/rq/queue.py
+++ b/rq/queue.py
@@ -231,10 +231,19 @@ class Queue(object):
         and kwargs as explicit arguments.  Any kwargs passed to this function
         contain options for RQ itself.
         """
-        timeout = parse_timeout(timeout) or self._default_timeout
+        timeout = parse_timeout(timeout)
+
+        if timeout is None:
+            timeout = self._default_timeout
+        elif timeout == 0:
+            raise ValueError('0 timeout is not allowed. Use -1 for infinite timeout')
+
         result_ttl = parse_timeout(result_ttl)
         failure_ttl = parse_timeout(failure_ttl)
+
         ttl = parse_timeout(ttl)
+        if ttl is not None and ttl <= 0:
+            raise ValueError('Job ttl must be greater than 0')
 
         job = self.job_class.create(
             func, args=args, kwargs=kwargs, connection=self.connection,
diff --git a/tests/test_queue.py b/tests/test_queue.py
index 463396e..750edde 100644
--- a/tests/test_queue.py
+++ b/tests/test_queue.py
@@ -237,6 +237,12 @@ class TestQueue(RQTestCase):
             None
         )
         self.assertEqual(q.count, 0)
+    
+    def test_enqueue_with_ttl(self):
+        """Negative TTL value is not allowed"""
+        queue = Queue()
+        self.assertRaises(ValueError, queue.enqueue, echo, 1, ttl=0)
+        self.assertRaises(ValueError, queue.enqueue, echo, 1, ttl=-1)
 
     def test_enqueue_sets_status(self):
         """Enqueueing a job sets its status to "queued"."""
@@ -264,6 +270,13 @@ class TestQueue(RQTestCase):
         job = queue.enqueue(echo, 1, job_timeout=15)
         self.assertEqual(job.timeout, 15)
 
+        # Not passing job_timeout will use queue._default_timeout
+        job = queue.enqueue(echo, 1)
+        self.assertEqual(job.timeout, queue._default_timeout)
+
+        # job_timeout = 0 is not allowed
+        self.assertRaises(ValueError, queue.enqueue, echo, 1, job_timeout=0)
+
     def test_default_timeout(self):
         """Timeout can be passed via job_timeout argument"""
         queue = Queue()