diff --git a/rq/queue.py b/rq/queue.py
index 8890d27..e5072cb 100644
--- a/rq/queue.py
+++ b/rq/queue.py
@@ -366,6 +366,8 @@ class Queue:
                     else:
                         # if pipeline comes from caller, re-raise to them
                         raise
+        elif pipeline is not None:
+            pipeline.multi()  # Ensure pipeline in multi mode before returning to caller
         return job
 
     def enqueue_call(self, func, args=None, kwargs=None, timeout=None,
diff --git a/tests/test_queue.py b/tests/test_queue.py
index 9d00545..510c671 100644
--- a/tests/test_queue.py
+++ b/tests/test_queue.py
@@ -539,6 +539,22 @@ class TestQueue(RQTestCase):
         self.assertEqual(job.timeout, Queue.DEFAULT_TIMEOUT)
         self.assertEqual(job.get_status(refresh=False), JobStatus.QUEUED)
 
+    def test_enqueue_job_with_no_dependency_prior_watch_and_pipeline(self):
+        """Jobs are enqueued only when their dependencies are finished, and by the caller when passing a pipeline."""
+        q = Queue()
+        with q.connection.pipeline() as pipe:
+            pipe.watch(b'fake_key')  # Test watch then enqueue
+            job = q.enqueue_call(say_hello, pipeline=pipe)
+            self.assertEqual(q.job_ids, [])
+            self.assertEqual(job.get_status(refresh=False), JobStatus.QUEUED)
+            # Not in queue before execute, since passed in pipeline
+            self.assertEqual(len(q), 0)
+            # Make sure modifying key doesn't cause issues, if in multi mode won't fail
+            pipe.set(b'fake_key', b'fake_value')
+            pipe.execute()
+            # Only in registry after execute, since passed in pipeline
+        self.assertEqual(len(q), 1)
+
     def test_enqueue_many_internal_pipeline(self):
         """Jobs should be enqueued in bulk with an internal pipeline, enqueued in order provided
         (but at_front still applies)"""