diff --git a/rq/defaults.py b/rq/defaults.py
index 2a3d57a..3744c12 100644
--- a/rq/defaults.py
+++ b/rq/defaults.py
@@ -93,4 +93,10 @@ https://docs.python.org/3/library/logging.html#logrecord-attributes
 DEFAULT_DEATH_PENALTY_CLASS = 'rq.timeouts.UnixSignalDeathPenalty'
 """ The path for the default Death Penalty class to use.
 Defaults to the `UnixSignalDeathPenalty` class within the `rq.timeouts` module
+"""
+
+
+UNSERIALIZABLE_RETURN_VALUE_PAYLOAD = 'Unserializable return value'
+""" The value that we store in the job's _result property or in the Result's return_value
+in case the return value of the actual job is not serializable
 """
\ No newline at end of file
diff --git a/rq/job.py b/rq/job.py
index a0574e6..61bc9aa 100644
--- a/rq/job.py
+++ b/rq/job.py
@@ -11,7 +11,7 @@ from redis import WatchError
 from typing import TYPE_CHECKING, Any, Callable, Dict, Iterable, List, Optional, Tuple, Union, Type
 from uuid import uuid4
 
-from .defaults import CALLBACK_TIMEOUT
+from .defaults import CALLBACK_TIMEOUT, UNSERIALIZABLE_RETURN_VALUE_PAYLOAD
 from .timeouts import JobTimeoutException, BaseDeathPenalty
 
 if TYPE_CHECKING:
@@ -887,7 +887,7 @@ class Job:
             try:
                 self._result = self.serializer.loads(result)
             except Exception:
-                self._result = "Unserializable return value"
+                self._result = UNSERIALIZABLE_RETURN_VALUE_PAYLOAD
         self.timeout = parse_timeout(obj.get('timeout')) if obj.get('timeout') else None
         self.result_ttl = int(obj.get('result_ttl')) if obj.get('result_ttl') else None
         self.failure_ttl = int(obj.get('failure_ttl')) if obj.get('failure_ttl') else None
diff --git a/rq/results.py b/rq/results.py
index 55ee971..fdbb763 100644
--- a/rq/results.py
+++ b/rq/results.py
@@ -6,6 +6,7 @@ from datetime import datetime, timezone
 from enum import Enum
 from redis import Redis
 
+from .defaults import UNSERIALIZABLE_RETURN_VALUE_PAYLOAD
 from .utils import decode_redis_hash
 from .job import Job
 from .serializers import resolve_serializer
@@ -181,7 +182,11 @@ class Result:
         if self.exc_string is not None:
             data['exc_string'] = b64encode(zlib.compress(self.exc_string.encode())).decode()
 
-        serialized = self.serializer.dumps(self.return_value)
+        try:
+            serialized = self.serializer.dumps(self.return_value)
+        except:  # noqa
+            serialized = self.serializer.dumps(UNSERIALIZABLE_RETURN_VALUE_PAYLOAD)
+
         if self.return_value is not None:
             data['return_value'] = b64encode(serialized).decode()
 
diff --git a/tests/test_results.py b/tests/test_results.py
index 9bc1b9e..4286cec 100644
--- a/tests/test_results.py
+++ b/tests/test_results.py
@@ -1,4 +1,5 @@
 import unittest
+import tempfile
 
 from datetime import timedelta
 from unittest.mock import patch, PropertyMock
@@ -7,6 +8,7 @@ from redis import Redis
 
 from tests import RQTestCase
 
+from rq.defaults import UNSERIALIZABLE_RETURN_VALUE_PAYLOAD
 from rq.job import Job
 from rq.queue import Queue
 from rq.registry import StartedJobRegistry
@@ -236,3 +238,19 @@ class TestScheduledJobRegistry(RQTestCase):
 
         Result.create(job, Result.Type.SUCCESSFUL, ttl=0, return_value=1)
         self.assertIsNone(job.return_value())
+
+    def test_job_return_value_unserializable(self):
+        """Test job.return_value when it is not serializable"""
+        queue = Queue(connection=self.connection, result_ttl=0)
+        job = queue.enqueue(say_hello)
+
+        # Returns None when there's no result
+        self.assertIsNone(job.return_value())
+
+        # tempfile.NamedTemporaryFile() is not picklable
+        Result.create(job, Result.Type.SUCCESSFUL, ttl=10, return_value=tempfile.NamedTemporaryFile())
+        self.assertEqual(job.return_value(), UNSERIALIZABLE_RETURN_VALUE_PAYLOAD)
+        self.assertEqual(Result.count(job), 1)
+
+        Result.create(job, Result.Type.SUCCESSFUL, ttl=10, return_value=1)
+        self.assertEqual(Result.count(job), 2)